QCM-I Mini 石英晶体微天平

with Impedance Measurement and Dissipation

The QCM-I Mini Quartz Crystal Microbalance is a high-sensitivity mass sensor which measures the change in frequency and dissipation of a quartz crystal resonator and any adsorbed film.  QCMs are useful in any number of applications - biosensors, chemical sensors, corrosion, polymer films, nanoparticle films, etc. Changes in frequency as well as dissipation give information relating to changes in mass or elasticity of films. 

The QCM-I, QCM-I Mini, and eQCM-I Mini are manufactured by MicroVacuum Ltd. (http://www.owls-sensors.com/) of Budapest, Hungary. MicroVacuum has integrated control of our USB-based potentiostats into their BioSense software (V3 or higher). Gamry has partnered with MicroVacuum for distribution of these instruments in the United States and China. Inquiries outside of the US and China can go directly to MicroVacuum (http://www.owls-sensors.com/contactus). 


QCM-I Mini Features:

  • Both frequency and quality of resonance (FWHM or Bandwidth or Dissipation) are measured
  • Different harmonics (up to the 13th Overtone at 5MHz Crystals) can be quickly and sequentially measured
  • Temperature control from 15° C to 60° (± 0,02° C) in included on one channel
  • Two independently measured channels
  • External PC with Windows® 10 Communication with QCM-I Mini via USB

software control measurement

 The software performs full control of the QCM-I Mini Instrument.  Two measurement modes are available:

  1. Resonance:  Measurement of resonance curve and calculation of the resonance frequency & FWHM up to 80 MHz
  2. QCM-t:  Continuous measurement of the resonance parameters and the temperature of the flow-cell.

Calculation:  Various QCM and ad-layer parameters can be calculated using standard or custom made models.  All these parameters can be displayed on the screen, printed, saved or can be exported for further evaluation.

What's Included:

  • QCM Unit with two channels (one channel is temperature controlled)
  • Microsoft® Surface Pro Tablet with Windows® 10 {ro
  • QSH-104 QCM Sensor Holder (flow through type)
  • BioSense 3.xx Software (one user license)

*Gamry is the exclusive distributor of MicroVacuum for the United States and China.  For information on other MicroVacuum Products or inquiries outside of the US & China, please visit their web site



Measuring Principle

The QCM-I Mini unit is a high sensitivity mass sensor which measures
the change in frequency of a quartz crystal resonator and
as a label free biosensor it measures the “wet mass” of the
adsorbed layer in processes occurring at or near the sensor
surface. The measuring principle is based on impedance analysis
of the quartz crystal. The resonant frequency (fres) and the
bandwidth of the resonant conductance curve are determined.
The bandwidth or full width at half maximum (FWHM) is in direct
correlation with the quality factor (Q) which is by definition
the inverse of the well known dissipation (D).

Measurement Channels 1-4
Frequency Range 1-80 MHz,up to the 13th overtone for a 5 MHz Crystal
Working Temperature

4° C to 80° C, controlled manually or via software,
stability ± 0.02° C

Sample Loading

Sample injection with external syringe or peristaltic pump unit
controlled manually or by BioSense software, and Rheodyne
Model 9725 manual injector valve, or Rheodyne MX series
semiautomatic switching valve.
Optional external Auto sampler unit is available

Flow Cell Volume

~ 40 µl (typical with Ø14 mm crystals)
Typical Flow Rates 0.01µl/min - 35ml/min with external syringe pump,
Syringe size 1-60 ml
Sample Volume  1 to 2000 µl (depends on installed loop volume)
Wetted parts  PTFE, PEEK, SS, VITON or Kalrez


Standard Resonance Frequency sensitivity ~2 x 10-1 Hz
Standard Dissipation Sensitivity in Liquid ~ 1 x 10-7
Mass Sensitivity in Liquid ≤ 1 ng/ cm2


Sensor Crystal 5 MHz, AT-cut, modular sensor holder accommodates
either 14 mm or 1” inch diameter crystals
See more details inQCM sensor datasheets.


BioSense  Universal software platform for OWLS, QCM & EC measurements
See more details in BioSense datasheet.
Import/Export of the measured data Between separate BioSense software and export to third party software
Excel, JPG, BPM, WMF etc.
PC Requirement USB 2.0, works with MS Windows® 7 or 8 or 10


Supply Voltage DC power supply with universal input voltage from
100V to 240V AC & 50 to 60 Hz.