Voltammetric method for simultaneous determination of ascorbic acid, paracetamol and guaifenesin using a sequential experimentation strategy
By Hendawy, Hassan A. M.; Ibrahim, Ahmed M.; Hassan, Wafaa S.; Shalaby, Abdalla; El-sayed, Heba M.
Published in Microchemical Journal
2019
Abstract
Cold is a leading cause of school and work absenteeism. Most cold over-the-counter medicines (OTC) contain paracetamol (PA), guaifenesin (GU) and other active ingredients. Ascorbic acid (AS) in pharmaceutical preparations is designed for preventing and treating respiratory viral infections. Thus, we report a robust voltammetric method for simultaneous determination of AS, PA and GU in their effervescent dosage form. The advantages of nanotechnology and chemometrics were combined to enhance the performance of electroanalysis. Fractional factorial design (FrFD) and dual response surface method (DRSM) were sequentially conducted. The method was validated in agreement with ICH guidelines; it showed accuracy over the concentration range of 11.3
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