Development of a novel micro biosensor for in vivo monitoring of glutamate release in the brain
By Ganesana, Mallikarjunarao; Trikantzopoulos, Elefterios; Maniar, Yash; Lee, Scott T.; Venton, B. Jill
Published in Biosensors and Bioelectronics
2019
Abstract
L- Glutamate is the main excitatory neurotransmitter in the central nervous system and hyperglutamatergic signaling is implicated in neurological and neurodegenerative diseases. Monitoring glutamate with a glutamate oxidase-based amperometric biosensor offers advantages such as high spatial and high temporal resolution. However, commercially-available glutamate biosensors are expensive and larger in size. Here, we report the development of 50
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