Chain Dynamics Limit Electron Transfer from Electrode-Bound, Single-Stranded Oligonucleotides

By Dauphin-Ducharme, Philippe; Arroyo-Curr
Published in The Journal of Physical Chemistry C

Abstract

A wide range of new devices aimed at in vivo molecular detection and point-of-care diagnostics rely on binding-induced changes in electron-transfer kinetics from an electrode-attached, redox-reporter-modified oligonucleotide as their signaling mechanism. In an effort to better characterize the mechanisms underlying these sensors, we have measured the electron-transfer kinetics associated with surface-attached, single-stranded DNAs modified with a methylene blue redox reporter either at the chain

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