Pyrenyl carbon nanostructures for ultrasensitive measurements of formaldehyde in urine
By Premaratne, Gayan; Farias, Sabrina; Krishnan, Sadagopan
Published in Analytica Chimica Acta
NULL
2017
Abstract
Abstract Measurement of ultra-low (e.g., parts-per-billion) levels of small-molecule markers in body fluids (e.g., serum, urine, saliva) involves a considerable challenge in view of designing assay strategies with sensitivity and selectivity. Herein we report for the first time an amperometric nano-bioelectrode design that uniquely combines 1-pyrenebutyric acid units pi-pi stacked with carboxylated multiwalled carbon nanotubes on the surface of gold screen printed electrodes for covalent attachment of NAD+ dependent formaldehyde dehydrogenase (FDH). The designed enzyme bioelectrode offered 6 ppb formaldehyde detection in 10-times diluted urine with a wide dynamic range of 10 ppb to 10 ppm. Fourier transform infrared, Raman, and electrochemical impedance spectroscopic characterizations confirmed the successful design of the {FDH} bioelectrode. Flow injection analysis provided lower detection limit and greater affinity for formaldehyde (apparent {KM} 9.6
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