Cathodic voltage-controlled electrical stimulation of titanium for prevention of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii biofilm infections
By Canty, Mary; Luke-Marshall, Nicole; Campagnari, Anthony; Ehrensberger, Mark
Published in Acta Biomaterialia
NULL
2017
Abstract
Abstract Antibiotic resistance of bacterial biofilms limits available treatment methods for implant-associated orthopaedic infections. This study evaluated the effects of applying cathodic voltage-controlled electrical stimulations (CVCES) of ?1.5 V and ?1.8 V (vs. Ag/AgCl) to coupons of commercially pure titanium (cpTi) incubated in cultures of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii (A. baumannii) as a method of preventing bacterial attachment. Stimulations were applied for 2, 4, and 8 h and coupon-associated and planktonic colony-forming units (CFU) were enumerated following stimulation. Compared to open circuit potential (OCP) controls, {CVCES} for 4 h at ?1.8 V significantly reduced coupon-associated {MRSA} {CFU} by 99.9% (1.30
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