Nanodiamonds on tetrahedral amorphous carbon significantly enhance dopamine detection and cell viability
By Peltola, Emilia; Wester, Niklas; Holt, Katherine B.; Johansson, Leena-Sisko; Koskinen, Jari; Myllym
Published in Biosensors and Bioelectronics
NULL
2017
Abstract
Abstract We hypothesize that by using integrated carbon nanostructures on tetrahedral amorphous carbon (ta-C), it is possible to take the performance and characteristics of these bioelectrodes to a completely new level. The integrated carbon electrodes were realized by combining nanodiamonds (NDs) with ta-C thin films coated on Ti-coated Si-substrates. {NDs} were functionalized with mixture of carboxyl and amine groups {NDandante} or amine NDamine, carboxyl {NDvox} or hydroxyl groups {NDH} and drop-casted or spray-coated onto substrate. By utilizing these novel structures we show that (i) the detection limit for dopamine can be improved by two orders of magnitude [from 10
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