Application of mixed self-assembled monolayers (Mixed SAMs) for nucleic acid detection
By Oral, Zehra Banu Bahsi
Published in Measurement
NULL
2016
Abstract
Abstract Mixed self-assembled monolayers (Mixed SAMs) consisting of 8-Ferrocenyl-1-octanethiol and 6-Mercapto-1-hexanol (FcOT:MCH) with probe {PNA} on gold electrodes were fabricated by using two-step after the optimization of immobilization temperature of FcOT:MCH SAMs. Using {AC} voltammetry, a novel nucleic acid detection platform, with mixed SAMs, was proposed. A negative formal potential shift was observed after complementary ssDNA hybridization while there was no significant difference after non-complementary ssDNA hybridization. Compatible results were obtained with the measurement of formal potential differences between mixed {SAMs} and target {DNA} (complementary and non-complementary DNA) in different target {DNA} concentrations. The formal potential difference between mixed {SAMs} immobilization and complementary ssDNA hybridization was measured in different ionic strength concentrations.
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