Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor
By Frankie J. Rawson and Jacqueline Hicks and Nicholas Dodd and Wondwossen Abate and David J. Garrett and Nga Yip and Gyorgy Fejer and Alison J. Downard and Kim H. R. Baronian and Simon K. Jackson and Paula M. Mendes
Published in ACS Applied Materials & Interfaces
NULL
2015
Abstract
Herein, we report a highly sensitive electrocatalytic sensor-cell construct that can electrochemically communicate with the internal environment of immune cells (e.g., macrophages) via the selective monitoring of a particular reactive oxygen species (ROS), hydrogen peroxide. The sensor, which is based on vertically aligned single-walled carbon nanotubes functionalized with an osmium electrocatalyst, enabled the unprecedented detection of a local intracellular
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