Gold-coated carbon nanotube electrode arrays: Immunosensors for impedimetric detection of bone biomarkers
By Madhumati Ramanathan and Mitali Patil and Rigved Epur and Yeoheung Yun and Vasselin Shanov and Mark Schulz and William R. Heineman and Moni K. Datta and Prashant N. Kumta
Published in Biosensors and Bioelectronics
NULL
2016
Abstract
C-terminal telopeptide (cTx), a fragment generated during collagen degradation, is a key biomarker of bone resorption during the bone remodeling process. The presence of varying levels of cTx in the bloodstream can hence be indicative of abnormal bone metabolism. This study focuses on the development of an immunosensor utilizing carbon nanotube (CNT) electrodes coated with gold nanoparticles for the detection of cTx, which could ultimately lead to the development of an inexpensive and rapid point-of-care (POC) tool for bone metabolism detection and prognostics. Electrochemical impedance spectroscopy (EIS) was implemented to monitor and detect the antigen
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