Novel Nanomonitor ultra-sensitive detection of troponin T
By Thomas W. Barrett and Nandhinee Radha Shanmugam and Anjan Panneer Selvam and Steven C. Kazmierczak and Shalini Prasad
Published in Clinica Chimica Acta
NULL
2015
Abstract
AbstractBackground Troponin is the preferred biomarker for diagnosing myocardial infarction. Point of care devices have not matched the sensitivity of laboratory-based methods for measuring troponin. The Nanomonitor is a novel point-of-care device that uses the change in electrical impedance that occurs when a biomarker binds to its antibody, which is then correlated to the concentration of the target biomarker. Methods Performance characteristics of the Nanomonitor were evaluated and compared to a standard laboratory-based method. Results The limit of detection of the Nanomonior for troponin T was 0.0088 ng/l. Total imprecission was 2.38% and 0.85% at troponin T concentrations of 73 ng/l and 1800 ng/l. The functional sensitivity (10% coeffecient of variation) was 0.329 ng/l. The linear regression had a slope of 0.996 (95% confidence interval, 0.991, 1.002), r = 1.00, and an intercept of 15.88 ng/l (95% confidence interval, ? 68.39 ng/l, 100.15 ng/l). The mean difference between the assays was ? 7.54 ng/l, determined by Bland
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