Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation

By Atmaramani, Rahul; Chakraborty, Bitan; Rihani, Rashed T.; Usoro, Joshua; Hammack, Audrey; Abbott, Justin; Nnoromele, Patrick; Black, Bryan J.; Pancrazio, Joseph J.; Cogan, Stuart F.
Published in Acta Biomaterialia 2019


We have characterized the in vitro and in vivo extracellular neural recording and stimulation properties of ruthenium oxide (RuOx) based microelectrodes. Cytotoxicity and functional neurotoxicity assays were carried out to confirm the in vitro biocompatibility of RuOx. Material extract assays, in accordance to ISO protocol

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