Development of a potentiometric maprotiline-selective electrode and its application in pharmaceut?cal samples
By Cavus, Ibrahim; Kanberoglu, Gulsah Saydan
Published in Microchemical Journal
2019
Abstract
A potentiometric ion selective electrode (ISE) was developed to determine the maprotiline, a tetracyclic pharmaceutical drug substance. Maprotiline-Tetraphenylborate ion pair was synthesized. Elemental analysis results showed that combination rate of Maprotiline-Tetraphenylborate ion pair was 1:1. The synthesized ion pair was used as sensing material in the structure of the electrode membrane. For membrane optimization, Polyvinylchloride (PVC) membrane ion selective electrodes were fabricated in different compositions using the synthesized ion pair and the potentiometric performance properties of these electrodes were investigated. We found that an electrode with a composition of 3.0% Maprotiline-Tetraphenylborate ion pair, 65.0% Dibutylphthalate, 32.0% Polyvinylchloride exhibited the best potentiometric performance properties. The linear working range of this electrode was 1.0
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